Role of selectins in experimental Staphylococcus aureus-induced arthritis
نویسندگان
چکیده
منابع مشابه
Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus.
We have previously described a murine model of hematogenously induced Staphylococcus aureus sepsis and arthritis. In this model, large numbers of granulocytes can be observed both in the circulation and locally in the inflamed synovium within 24 h after bacterial inoculation. To assess the role of neutrophils in this severe infection, mice were given granulocyte-depleting monoclonal antibody RB...
متن کاملHistopathological and serological progression of experimental Staphylococcus aureus arthritis.
In a newly developed mouse model of Staphylococcus aureus arthritis the kinetics of joint destruction and serological manifestations as well as the clinical course of arthritis and osteitis were studied. Almost all mice developed histopathological signs of arthritis upon a single intravenous injection of 10(7) S. aureus LS-1 cells. There was rapid joint destruction, with synovial hypertrophy al...
متن کاملGranulocyte-macrophage colony-stimulating factor in Staphylococcus aureus-induced arthritis.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that is able to increase not only the production of phagocytic cells but also their efficacy with respect to, e.g., bactericidal properties. In this study, we wanted to analyze the impact of GM-CSF on experimental Staphylococcus aureus-induced arthritis. For that purpose, mice were administered GM-CSF before and after bacte...
متن کاملRole of monocytes in experimental Staphylococcus aureus endocarditis.
In the pathogenesis of bacterial endocarditis (BE), the clotting system plays a cardinal role in the formation and maintenance of the endocardial vegetations. The extrinsic pathway is involved in the activation of the coagulation pathway with tissue factor (TF) as the key protein. Staphylococcus aureus is a frequently isolated bacterium from patients with BE. We therefore investigated whether S...
متن کاملStaphylococcus aureus triggered reactive arthritis.
OBJECTIVES To report two patients who developed reactive arthritis in association with Staphylococcus aureus infection. METHODS A review of the case notes of two patients. RESULTS Two adult female patients have developed sterile arthritis in association with Staph aureus infection. The first patient has had two episodes of arthritis; the first followed olecranon bursitis, the second followe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2000
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(200006)30:6<1606::aid-immu1606>3.0.co;2-8